Breast Tumors Expression of the Steroid Receptor RNA Activator in Human
نویسندگان
چکیده
The expression of the recently described steroid receptor RNA activator (SRA) was measured by semiquantitative reverse transcription-PCR within 27 independent breast tumors, spanning a wide spectrum of grade and estrogen receptor (ER) and progesterone receptor (PR) levels. Subgroup analysis showed that SRA expression was similar in ER1/PR1 (median 5 65.5, n 5 8) and in ER2/PR2 (median 5 94.6, n 5 5) tumors. Interestingly, SRA expression in these two subgroups was significantly (Mann-Whitney rank-sum test, P < 0.05) lower than that observed in ER1/PR2 (median 5 156.4, n 5 6) and ER2/PR1 (median 5 144.8, n 5 8) tumors. A variant form of SRA, presenting a deletion of 203 bp within the SRA core sequence, was also observed in breast tumor tissues. The relative expression of this new SRA isoform correlated with tumor grade (Spearman coefficient r 5 0.53, n 5 27, P 5 0.004). These data suggest that changes in the expression of SRA-related molecules occur during breast tumor progression.
منابع مشابه
Expression of the steroid receptor RNA activator in human breast tumors.
The expression of the recently described steroid receptor RNA activator (SRA) was measured by semiquantitative reverse transcription-PCR within 27 independent breast tumors, spanning a wide spectrum of grade and estrogen receptor (ER) and progesterone receptor (PR) levels. Subgroup analysis showed that SRA expression was similar in ER+/PR+ (median = 65.5, n = 8) and in ER-/PR- (median = 94.6, n...
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